Effects of Systemic Inflammation on Endothelium-Dependent Vasodilation
نویسندگان
چکیده
منابع مشابه
Hyperlipoproteinemia impairs endothelium-dependent vasodilation.
Atherogenic lipoproteins can cause endothelial dysfunction in the initial stage of atherogenesis. In our study we examined 134 patients with defined hyperlipoproteinemia (non-HDL cholesterol>4.1 mmol/l or triglycerides>2.5 mmol/l or taking any of lipid lowering drugs)--94 men and 40 women. The subgroup of controls of comparable age contained 54 normolipidemic individuals--30 men and 24 women. P...
متن کاملAcute systemic inflammation impairs endothelium-dependent dilatation in humans.
BACKGROUND We tested the hypothesis that endothelial dysfunction underlies the association between an acute inflammatory episode and the transiently increased risk of a cardiovascular event by examining the effects of an experimental inflammatory stimulus on endothelium-dependent vasodilation. METHODS AND RESULTS Salmonella typhi vaccine was used to generate a systemic inflammatory response i...
متن کاملImpact of ageing on the measurement of endothelium-dependent vasodilation.
Two established methods to assess endothelium-dependent vasodilation in the peripheral circulation have been used in epidemiological research, the invasive forearm technique using intra-brachial infusion of acetylcholine (EDV) and flow-mediated vasodilation (FMD) of the brachial artery using ultrasound Both EDV and FMD have proven to predict future cardiovascular events in patient populations a...
متن کاملEndotoxin-induced and vaccine-induced systemic inflammation both impair endothelium-dependent vasodilation, but not pulse wave reflection
BACKGROUND Inflammation induced by either endotoxin or vaccination has previously been shown to impair endothelium-dependent vasodilation (EDV) in healthy young individuals. However, the vascular effects of these two mechanisms of inducing inflammation have not been compared in the same individuals. METHODS Twelve young healthy males were studied at the same time of the day on three occasions...
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ژورنال
عنوان ژورنال: Trends in Cardiovascular Medicine
سال: 2006
ISSN: 1050-1738
DOI: 10.1016/j.tcm.2005.10.002